Īccording to the previous studies, low utilizations of consistent condom use have been associated with different factors. Deprived of any interventions, the annual rate of HIV transmission is 6.3% among the negative serodiscordant partners. Among HIV serodiscordant couples with HIV, 65-85% have acquired the infection from their partners. The issue is significantly high in sub-Saharan Africa, including Ethiopia. The problem is dominant among the serodiscordant couples. ĭespite its significance, consistent condom use is underutilized. Currently, many countries are getting on the fast-track targets to end the AIDS epidemic by 2030 as part of the Sustainable Development Goals. The world has exceeded the AIDS targets of the Millennium Development Goal (MDG) 6, halting and reversing the spread of HIV. Among those prevention methods, consistent and correct condom use is a critical component in a comprehensive and sustainable approach to the prevention of HIV. Ībstaining from sex, having sex with only one uninfected partner, using condoms are well-known ABC methods of preventing HIV transmission. These include sociodemographic, personal behavior, cultural, and lack of awareness. As per the findings of previous studies, the risk of transmission among serodiscordant couples is predicted by many variables. The percentage of serodiscordant partnerships is 0–6% in generalized epidemics and 9–17% in concentrated epidemics of HIV. In sub-Saharan Africa, it is estimated that half of the HIV-positive people have a negative couple. Repeated low-risk sexual acts will be translated into a significant cumulative risk over time, especially with unprotected sexual experiences. The majority of new infections of HIV are through the heterosexual transmission of HIV among the serodiscordants. The vast majority of people living with HIV (PLWHA) are from low-and middle-income countries including Ethiopia. Sub-Saharan Africa is the most affected region that accounts for about two-thirds of the global total new HIV infections. The disease has claimed more than 35 million lives globally. Human immunodeficiency virus (HIV) continues to be a significant public health issue. There should be an increased focus on student and employee intervention as well. To improve condom use consistently, planners, policymakers, and health care practitioners should consider the factors listed above when making decisions. Despite its importance, the proportion of consistent condom use among serodiscordant couples was significantly low. After controlling for all other variables, unmarried partners, and students and employees, and, respectively, were less likely consistently use condoms, whereas couples living together,, receiving counseling about condom use,, and having more knowledge about HIV, were more likely to use condoms consistently. This study confirmed that the proportion of consistent condom use was 58.4%. The statistical significance of the variables was declared at a value of less than 0.05. Multivariable logistic regression was conducted to identify factors associated with consistent condom use. Qualitative data were collected using gender-matched four focus group discussions. An interviewer-administered questionnaire was used to collect the data. For the quantitative findings to be more robust and reliable, a qualitative design was incorporated. A cross-sectional was conducted from October 2019 to June 2020. Consequently, the current study looked at the proportion of serodiscordant couples in Ethiopia who used condoms consistently and the factors associated with that. Although consistent condom use can significantly reduce HIV transmission risk among serodiscordant couples, it has not been extensively studied in Ethiopia. Heterosexual transmission within serodiscordant relationships is the core source of new HIV infections.